Synapsin Condensates Recruit alpha-Synuclein
نویسندگان
چکیده
منابع مشابه
Calcium: Alpha-Synuclein Interactions in Alpha-Synucleinopathies
Aggregation of the pre-synaptic protein, α-synuclein (α-syn), is the key etiological factor in Parkinson's disease (PD) and other alpha-synucleinopathies, such as multiple system atrophy (MSA) and Dementia with Lewy bodies (DLB). Various triggers for pathological α-syn aggregation have been elucidated, including post-translational modifications, oxidative stress, and binding of metal ions, such...
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at present, when a clinical diagnosis of parkinson’s disease (pd) is made, serious damage has already been done to nerve cells of the substantia nigra pars compacta. the diagnosis of pd in its earlier stages, before this irreversible damage, would be of enormous benefit for future treatment strategies designed to slow or halt the progression of this disease that possibly prevents accumulation o...
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Synucleinopathies are a group of neurodegenerative disorders that share common pathological intracellular deposits that contain aggregates of the protein ┙-synuclein. Substantial evidence suggests that fibril formation by ┙-synuclein is a critical step in the development of Parkinson's disease (PD). Indeed, in vitro, ┙-synuclein forms fibrils with morphologies and staining characteristics simil...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2021
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2021.166961